What are the age-related changes in hormone production?
Patients with Late-Onset Hypogonadism (LOH) show symptoms comparable with those of the classical male hypogonadism. These often include loss of libido, erectile dysfunction, loss of vigor and energy, physical weakness, depression, and increased visceral fat (measured by waist circumference). Several studies (Massachusetts Male Aging Study in 1991, Vermeulen Study in 1972) have confirmed that the levels of testosterone decrease with age, i.e., from 40 years of age by approximately 1.2 % annually. Between 40 and 70 years of age, therefore, a man loses approximately 35 % of his normal daily testosterone production.
