What are the advantages with photodynamic therapy for treating skin precancers?
The greatest advantage of PDT is the ability to selectively treat an entire area of skin damage and precancers (blanket or field treatment). PDT generally decreases the likelihood of lighter or darker skin spots (post-inflammatory hyper- or hypopigmentation) caused by routine freezing with liquid nitrogen. Additionally, PDT frequently may facilitate smoother skin and an overall improved appearance, tone, color, and enhanced skin texture. In several studies, PDT has been preferred by many patients for ease of use and recovery as compared to alternative treatments including freezing and chemotherapy creams like fluorouracil (Efudex). The PDT side effects may be milder with less downtime than with fluorouracil. For patients with many skin lesions, PDT may be generally more effective than repeated spot treatment with topical liquid nitrogen. Some patients are unable to tolerate the prolonged treatment required with fluorouracil or imiquimod (Aldara) because of the irritation, redness, and
