What are the advantages of transgenic animal compared with traditional production methods?
Several methods are currently used for industrial production of proteins: Bacterial systems (E. Coli), are commonly used and very efficient. They offer low costs of production. But there utilization remains limited to the production of simple non-glycosylated proteins that do not require sophisticated folding processes. Purification of proteins derived from bacterial fermentation is also often difficult to set up. Fungal systems allow efficient production of some secreted proteins. Glycosylation in these systems add a number of mannoses which strongly affect the pharmacokinetics properties of the protein. Baculovirus systems can produce a wide range of proteins but have yet to be scaled-up to industrial levels. Mammalian cell culture is the standard method for producing glycosylated proteins, (i.e. monoclonal antibodies). It offers properly folded glycosylated proteins. A large number of recombinant proteins are manufactured this way. However capital investment to build mammalian cell
