What are the advantages of the RCCS bioreactor over other 3-D cell culture systems?
3D extracellular matrices with embedded cells in a dish or multi-well plate have been most commonly used recently for 3-D cell culture. While this model produces reasonably good 3D tissue models, it is limited by restricted mass transfer (due to the static nature of the culture and also because the matrix presents an additional barrier to mass transfer) and lack of scalability. Dynamic culture systems such as spinner flasks, or, on a larger scale, stirred tanks provide very good mass transfer, but these systems use mechanical force which will not only damage the cells, but also prevent their aggregation. As described earlier, RCCS bioreactors provide excellent mass transfer and low mechanical- stress conditions that allow the formation of 3D aggregates. Several studies have been conducted with these bioreactors that have shown the superiority of these bioreactors for 3D cell culture. Click on the following link for a brief look at the various studies that have successfully utilized RCC
Related Questions
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- What are the advantages of the RCCS bioreactor over other 3-D cell culture systems?
