What are some potentially dangerous drug interactions with methadone?
Probably the most common combination and most dangerous combination is methadone with a benzodiazepine like Valium. This combination can be fatal by stopping breathing. Some anti-depressants like Elavil can lead to cardiac complications when used with methadone. Even the SSRI anti-depressants, like Prozac, can lead to problems with methadone. Some antibiotics (Cipro, clarithromycin) and antifungals (Fluconazole) interact with methadone. The message here is that you should go over you list of medications with your doctor and pharmacist before starting methadone. Adjustments or alternatives may be needed.
