What are some of the promising areas of research in nonmelanoma skin cancer prevention?
Dr. DiGiovanna: Isotretinoin (Accutane), a derivative of vitamin A, has been studied as an agent to prevent cancers in patients at high risk, and it has been effective in studies of XP patients, who develop large numbers of skin cancers. T4N5 liposome lotion (Dimericine) has been shown to absorb into skin fairly well and, in one study, to prevent new skin cancers in XP patients. It is another approach to chemoprevention. Clinical trials using Celecoxib in patients with actinic keratoses, a precancerous condition, are also taking place. Dr. Kraemer: Discovering the basic mechanism that creates skin cancer is the most important research; looking at it from initiation, promotion, precancer to cancer. We are learning about what is happening at each of those stages and want to try to find ways to interrupt the process and prevent cancer. How successful have retinoids, such as isotretinoin, been in preventing skin cancer? Dr. Kraemer: We did a study here a few years ago with Accutane, which
Related Questions
- I understand that 50% of our prevention strategies need to be research based, but do the 50% that are considered promising have to come from the list that was provided by SICA?
- What are some of the promising areas of research in nonmelanoma skin cancer prevention?
- Are there other areas of research that look promising for potential treatments for RP?
