What are some of the key benefits surrounding the use of zebrafish specifically?
The zebrafish is a vertebrate, so it has most of the organ systems and physiological functions that humans have. Numerous zebrafish disease models have already been developed, the zebrafish genome has been sequenced, and genomic tools like microarrays and cDNA collections are well developed. Zebrafish are prolific and inexpensive to raise, and in embryonic and larval stages fit easily in the wells of 384-well plates. Another advantage is their transparency, which permits organ morphology and function to be monitored in the living organism using rapid, robust imaging tools. Finally, unlike many other model organisms, zebrafish absorb compounds readily from their surrounding environment; treatments can be performed simply by adding compounds to their water. GLASS HOUSES: Angiograms highlighting the vasculature of a pair of mutant zebrafish. The defect in the upper fish has been suppressed by treatment with the small molecule GS4012. The background shows human endothelial cells induced to
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