What are some examples of major successes in public/private partnerships when it comes to vaccine development?
Dr. Philip Arlen: There are therapeutic vaccines and preventative vaccines– a good example for preventative vaccines is the work of Drs. Douglas Lowy and John Schiller here at NCI which has led to the development of the HPV vaccine that is being utilized not only in the U.S., but all over the world commercially. Currently, no therapeutic [treatment] vaccine has been approved by the FDA. However, a couple of examples of partnerships resulting with private industry and NCI/academia include: – The PSA-TRICOM vaccine was developed at NCI, and initially involved a partnership with Therion Biologics. [This partnership] resulted in a number of promising Phase II studies with the vaccine in prostate cancer. A CRADA [Cooperative Research and Development Agreement] to work with the NCI and Bavarian Nordic (BN) ImmunoTherapeutics Inc., to further develop this vaccine is now ongoing. – A partnership with Globeimmune Inc. and the NCI through a CRADA has resulted in a Saccharomyces-CEA based vaccin
