What are some current issues and controversies about vitamin A?
Vitamin A, beta carotene, and cancer Dietary intake studies suggest an association between diets rich in beta-carotene and vitamin A and a lower risk of many types of cancer [32]. A higher intake of green and yellow vegetables or other food sources of beta carotene and/or vitamin A may decrease the risk of lung cancer [2,33-34]. However, a number of studies that tested the role of beta-carotene supplements in cancer prevention did not find them to protect against the disease. In the Alpha-Tocopherol Beta-Carotene (ATBC) Cancer Prevention Study, more than 29,000 men who regularly smoked cigarettes were randomized to receive 20 mg beta-carotene alone, 50 mg alpha-tocopherol alone, supplements of both, or a placebo for 5 to 8 years. Incidence of lung cancer was 18% higher among men who took the beta-carotene supplement. Eight percent more men in this group died, as compared to those receiving other treatments or placebo [35]. Similar results were seen in the Carotene and Retinol Efficacy
