What are some contraindications to specific antidepressants?
Absolute contraindications to specific antidepressants include: allergy to the antidepressant; nefazodone in combination with cisapride; and bupropion for a patient with seizures. Relative contraindications to specific antidepressants include: tricyclic antidepressant for a patient with symptomatic benign prostatic hyperplasia, troublesome constipation, symptomatic or unstable ischemic heart disease, or orthostatic hypotension; trazodone for a patient with orthostatic hypotension; and SSRI for a patient with anorexia and significant weight loss. Venlafaxine may increase blood pressure, particularly at higher doses. • What are the consequences of the drug selection for the facility? If the facility uses a drug formulary, the practitioner should be familiar with the antidepressants on the formulary (including available strengths for titration and available forms of the drug [e.g., liquid, slow-release]). However, if no medication on the formulary is considered appropriate, steps should b
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