What are potential side effects from NSAIDs?
About 1% of pets taking NSAIDs have a problem or side effect because of the drug. A common NSAID side effect is gastric ulcer. The pet may refuse to eat, vomit, and pass dark, tarry stool. Another side effect is kidney damage, causing the pet to drink more and urinate more, a condition called PUPD, or polydipsia, polyuria. Pets may become anemic with pale gums, or they may have yellow (icteric) gums. It is also common for NSAIDs to damage the liver. Fortunately, for most pets the organs return to normal when the NSAID is withdrawn. In humans, some COX 2 inhibitors affected prostaglandins that protected the heart so that some people taking these drugs suffered heart attacks. Pets don’t have the same predisposition to heart attack as humans do, but research has not clarified the full effect COX 2-inhibiting NSAIDs will have on pet hearts.
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