WHAT ARE NEW MEDICATIONS FOR PANIC DISORDER?
Adapted from Gorman JM, New and Experimental Pharmacological Treatments for Panic Disorder, in Wolfe & Maser: Drugs that selectively block presynaptic neuronal reuptake of serotonin (SSRIs) are fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox), and venlafaxine (Effexor). Studies have documented that fluoxetine and fluvoxamine reduce panic attacks and avoidance behavior. Many clinicians in the United States already prescribe fluoxetine and sertraline for panic patients, often as the drug of first choice. The serotonin reuptake blockers have a favorable side effect profile compared with currently available antipanic drugs. However some patients have a hypersensitivity reaction when fluoxetine treatment is initiated at 20 mg/day. Consequently, initiation of therapy at lower dosages is often recommended. Buspirone, a 5-HT1a partial agonist, has been shown to be equally effective as benzodiazepines in the treatment of GAD (Generalized Anxiety Disorder). Howev
