What are MIC & MBC?
– MIC is minimum inhibitory concentration. It is the highest dilution of an antibiotic that inhibits the growth of bacteria. – MBC is minimum bactericidal concentration. It is the highest dilution of an antibiotic that kills the bacteria. 11. Name two drugs, when given in combination, are additive or synergistic. – Penicillin and Gentamicin; Amoxycillin and Clavulanic acid; Trimethoprim and sulphamethoxazole. ( Several drugs are given together in the treatment of tuberculosis to achieve synergistic killing and to prevent the emergence of drug resistance against any one of them) 12. Name two drugs, when given in combination, are antagonistic. – Penicillin and Tetracycline (since one is bactericidal and the other is bacteriostatic). 13. Name some bactericidal and bacteriostatic drugs. – Penicillins, Cephalosporins, Aminoglycosides etc., are bactericidal while Chloramphenicol and Tetracycline are bacteriostatic.
