What are H1 and H2?
Mast cells release 3 known types of histamine, H1, H2, H3. It is believed there are also H4 and H5 histamine. Skin has receptors at least for H1 and H2. Airways have receptors for H1, the gastrointestinal (GI) tract has receptors for H2, and the brain is believed to have H3 receptors. The H1 drugs are those commonly thought of as antihistamines, such as Zyrtec, Benadryl, Claritin, Allegra, and Atarax. The H2’s are normally thought of as ulcer medications, but are actually histamine 2 blockers. Zantac, Pepcid, Axid and Tagamet are the most common.