What are examples of conflicts of interests that should be avoided by DSMB members?
Conflicts of interest aren’t always easy to define. They can be both financial and intellectual. If you work for the sponsor, even if you’re not involved in the study, that would be an obvious conflict to avoid. If you were on the speakers circuit for the sponsor on its product, that might be viewed as a conflict. Where it gets more challenging is when you have a grant or contract with any company or agency to do research in the same area as the one under investigation in the clinical trial. You would have to take a careful look at those relationships. On the one hand, you want DMSB members to have experience and knowledge about the research, which means they are probably conducting research on this topic funded by some sponsor, perhaps even a competitor. On the other hand, if the relationship with the sponsor is too close, the DSMB member might not be perceived as being independent. Where to draw the line is not always clear. If absolute separation were demanded, the level of expertis
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- What are examples of conflicts of interests that should be avoided by DSMB members?
