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What are Ca-DTPA and Zn-DTPA?

April 26, 2017ca-dtpa zn-dtpa

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What are Ca-DTPA and Zn-DTPA?

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Calcium-DTPA (Ca-DTPA) and Zinc-DTPA (Zn-DTPA) are drug products that have been used investigationally for over 40 years to speed up excretion of the transuranium elements plutonium, americium, and curium from the body. Ca-DTPA and Zn-DTPA bind to these elements and are then excreted in the urine. The FDA has found that when produced under conditions specified in approved new drug applications (NDAs), both of these products can be safe and effective for the treatment of internal contamination with plutonium, americium, or curium. Ca-DTPA and Zn-DTPA do not treat contamination with radioactive iodine, uranium and neptunium, or the complications of radiation exposure (e.g., bone marrow suppression). Other treatments should be initiated if these conditions are suspected. 3. What are plutonium, americium, and curium? Plutonium, americium, and curium are transuranium elements (elements with atomic numbers higher than uranium). All transuranium elements are radioactive. In addition to their