What additional tests might be indicated for the evaluation of fever of unknown origin?
Any additional testing depends entirely on the combined results of the history, physical examination, and screening tests. It is impossible to list all possible additional tests. However, here are a few examples of common additional tests. If the initial screening tests indicate a problem with an organ such as the liver or kidneys, or the presence of a tumor, then imaging studies (radiography or ultrasound) of these organs or masses may be suggested, along with fine needle aspiration biopsy or tissue biopsy in order to determine what cell types are present. Large increases in globulins detected with the serum biochemistry profile may indicate the need for a serum protein electrophoresis. This test will help us to decide if the increase in these serum proteins is due to inflammation or due to underlying malignancy. An animal with clinical signs of lameness may need to undergo joint taps. This procedure involves removing a small amount of joint fluid using a sterile needle. The joint flu