What action did CDC take when cases of intussusception were reported to VAERS?
CDC, in collaboration with the FDA, and state and local health departments throughout the US conducted two large investigations. One was a multi-state investigation which evaluated whether or not rotavirus vaccine was associated with intussusception. Based on the results of the investigation, CDC estimated that RotaShield vaccine increased the risk for intussusception by 1 or 2 cases of intussusception among each 10,000 infants vaccinated. The other was a similar investigation in children vaccinated at large managed care organizations. When the results of these investigations were became available, the Advisory Committee on Immunization Practices (ACIP) withdrew its recommendation to vaccinate infants with RotaShield vaccine, and the manufacturer voluntarily withdrew RotaShield from the market in October 1999.
