What abbreviations are used for parameters in the Pharmacokinetics/Metabolism Knowledge Area?
• AUC (A-B) — Area under curve for a given interval from time A to time B in hours • BR (A-B) — Biliary recovery between time A and time B (in hours). • Cl — Clearance; the rate of elimination by all routes ( or by specified route(s) and mechanism(s) of elimination, as indicated by a letter in parenthesis • Cl(B) — Biliary clearance • Cl(H) — Hepatic clearance • Cl(R) — Renal clearance • Cl(XR) — Extra-renal clearance • Cmax — Peak concentration • Cmin — Trough concentration • Css — Average plasma concentration of an administered drug at steady state. • ER (A-B) — Recovery in exhaled air from time A to time B (in hours) • F — Bioavailability • FR (A-B) — Fecal Recovery between time A and time B (in hours) • ka — Absorption constant • kel — Elimination rate constant • MAT — Mean Adsorption Time • MR — Milk Recovery • MRT — Mean Retention Time • PB — Protein Binding • Q — Intercompartmental clearance • t1/2 — Half-life • tlag — Lag time • Tmax — Time to peak concentration • Tss — Time to
