Were there any “solutions” to bring leptin levels back to normal?
Keith [Not that I saw, since I do not believe the study was a weight–loss experiment. Still, remember that lowering leptin levels in an obese person will only worsen the problem, because leptin antagonizes NPY, the hunger signal. Although it is unclear, it would seem that something about weight loss reduces or removes the protein that blocks the MC4 receptor. At that point leptin again can be effective…or maybe not. This could explain the “Oprah syndrome” – people who lose a lot of weight and then gain it back: levels of the MC4 blocker never diminish despite the weight loss. Speculation.
