Vitamin E is fat soluble, what about liver toxicity, what level is safe?
Unlike other fat soluble vitamins, vitamin E is NOT accumulated in the liver. This astonishing fact was recently proven in a paper entitled, Vitamin E Trafficking.* The authors report, “the liver does not accumulate ‘toxic’ amounts of vitamin E. Excess vitamin E is not accumulated in the liver, but is excreted, mostly in bile, via a p-glycoprotein (ABCB4)-mediated process.” Ann. N.Y. Acad. Sci. 1031: 1–’D012 (2004). doi: 10.1196/annals.1331.001 Vitamin E Trafficking Maret G. Trabera, Graham W. Burtonb and Robert L. HamiltoncaLinus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA; bOccell, Inc., Ottawa, Ontario K1B 5B0, Canada; cDepartment of Anatomy, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA Kappus H, Diplock AT. Tolerance and safety of vitamin E: a toxicological position report. Free Radic Biol Med 1992;13:55–’D074. Vitamins E and C are safe across a broad range of intakes. Hathcock JN, Azzi A, Blumberg J,
