USB or Firewire?
Many hard drive enclosures have Firewire, USB, or both interfaces for connecting the hard drive to your computer. Either of these interfaces will work fine for backing up and safeguarding your data, however, PowerPC Macs cannot boot from USB-attached hard drive enclosures. While Intel-based Macs can boot from either, I generally recommend using Firewire for performance reasons. Backups over Firewire are always faster than backups over USB.
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