Transdermal clonidine: does it affect pain after abdominal hysterectomy?
Author(s): Dimou P, Paraskeva A, Papilas K, Fassoulaki A Affiliation(s): Department of Anesthesia, St Savas Hospital, Athens. Publication date & source: 2003, Acta Anaesthesiol Belg., 54(3):227-32. Publication type: Clinical Trial; Randomized Controlled Trial Clonidine has analgesic properties. We evaluated the analgesic effect of clonidine perioperatively. Forty patients undergoing abdominal hysterectomy received randomly the evening before surgery transdermal clonidine covered with overlay (CLO group) or the overlay alone (CTL group). Ten min before induction they received i.v. clonidine 1 microgram.kg-1 (CLO) or normal saline (CTL). Induction was accomplished with fentanyl 5 micrograms.kg-1, thiopentone 5 mg.kg-1, cis-atracurium 0.15 mg.kg-1 and maintenance with sevoflurane 2% in 70% N2O. Hemodynamic parameters were recorded intraoperatively. Pain was assessed by VAS at rest and movement 2, 4, 6, 8, 24, 48, 72 h and 30 days, postoperatively. During the first 8 h postoperatively all
