This test is 100% reliable (OK: 99,999%) for the very question it is asking: does this cat have or does this cat not have this specific MyBPC mutation in its genotype (DNA)?
There are no “false positives”: a positive test means the cat has the mutation and should not be bred. It is also likely to have or develop HCM, no matter if it shows signs of the disease or not. There are no “healthy carriers”. As this mutation is a dominant one, it doesn’t matter whether the cat is heterozygous or homozygous. To put in very plain terms: if the cat has the mutation, the cat is HCM positive. The DNA test being used (sequencing) is reliable. There’s no magic about it: these are specific DNA molecules being sequenced. A mutated codon (CCC) can’t be mixed up with a “regular” one (GCC). No tricky false positives! There are no false negatives either. The two Maine Coon cats with HCM whose DNA test was negative are not “false negatives”. The negative result doesn’t mean the test doesn’t work, it means the cat has developed HCM for another reason (most likely a different mutation) than this causative mutation. It doesn’t change the fact this mutation is causative, and a cat d
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