The R group in a protein structure, can this be any element (C,H,O,N,S) or does it have to be a sulphur element?
A. OK, the R-group will usually contain some combination of C, O, N and H, although not all 20 will necessarily have N and/or oxygen. It varies! BUT only 2 of the 20 amino acids actually have S in their R-group. Do a google search (images) for amino acids and you will be able to see how the R-group varies. Important- you do not need to know the R-group structures of each amino acid, just that they are the variable region between the different amino acids and that a couple also contain the element S.
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