Testicular leukocytes: what are they doing?
MP Hedger Leukocytes, specifically macrophages, lymphocytes and mast cells, are found within the testes of most, if not all, mammals. In some species (for example, rats, mice and humans), the number of ‘resident’ testicular macrophages, in particular, is quite considerable. However, reproductive biologists are only beginning to explore the characteristics and possible biological significance of these cells. As in other tissues, the testicular leukocytes are involved in immunological surveillance, immunoregulation and tissue remodelling. They are implicated in the mechanisms that make the testis a particularly successful site for tissue transplantation in some experimental animals. Moreover, recent studies have demonstrated that the testicular macrophages have specific trophic effects on Leydig cell development and steroidogenesis. In turn, the development and functions of the testicular leukocyte population are clearly influenced by the testicular environment, and especially by the Ley
