Since VZIG is no longer produced, what are the current options for an immunocompromised individual or a pregnant woman with no known immunity who is exposed to varicella?
There is an investigational new product known as VariZIG that can be used for immunocompromised individuals or for pregnant women. Remember, this is a concern if the individual is susceptible to chickenpox. Instructions on the use of VariZIG are available in MMWR 2006; 55:209-210. VariZIG must be given within the first 96 hours following exposure. For immunocompromised persons, if this product cannot be obtained, IGIV can be administered – also within 96 hours. If a pregnant woman cannot receive VariZIG within 96 hours, she can be administered IGIV or can be followed for signs of rash and treated with acyclovir if a rash appears.
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