Since LAIV is a live virus, what are the possibilities for transmitting infection to ill patients or family members?
Available data indicate that both children and adults vaccinated with LAIV can shed vaccine viruses after vaccination, although in lower amounts than occur typically with shedding of wild-type influenza viruses. In rare instances, shed vaccine viruses can be transmitted from vaccine recipients to non-vaccinated persons. However, serious illnesses have not been reported among unvaccinated persons who have been infected inadvertently with vaccine viruses. What is the efficacy of TIV?1 The efficacy of TIV depends on age and immunocompetence of the vaccine recipient and the degree of match between influenza vaccine viruses and circulating influenza viruses.
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