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Should sFLC tests be used as a screen for monoclonal gammopathies instead of SPE?

April 26, 2017gammopathies monoclonal screen sflc spe tests Used

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Should sFLC tests be used as a screen for monoclonal gammopathies instead of SPE?

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No. SPE detects intact immunoglobulin monoclonal proteins and some FLC monoclonal proteins. In contrast, sFLC assays detect FLC monoclonal gammopathies, either alone, or in association with intact monoclonal immunoglobulins. Approximately 95% of patients with intact monoclonal immunoglobulins have abnormal sFLCs, but not all, particularly those patients with low concentration MGUS.