Should pregnant women who have received the smallpox vaccine receive Vaccinia Immune Globulin (VIG)?
Vaccinia Immune Globulin (VIG) is a treatment that can be used to help people who have certain serious reactions to smallpox vaccine. VIG is made from the blood of people who have gotten the smallpox vaccine more than once. It contains substances (antibodies) that give protection from vaccinia infection. Women should contact their healthcare provider regarding use of VIG. Currently, CDC’s Advisory Committee on Immunization Practices does not recommend preventive use of Vaccinia Immune Globulin (VIG) for pregnant women. However, if a woman has another complication from smallpox vaccine that could be treated with VIG, it is ok for her to receive it while she is pregnant.