Should magnesium sulfate be used for fetal neuroprotection?
The author ponders the potential of magnesium sulfate to provide fetal neuroprotection and prevent cerebral palsy (CP). Investigators believe neuroprotection is possible through reduced vascular instability and hypoxia-reperfusion injury and/or reductions in cytokine- or excitatory amino acid-induced damage. Studies showing the ability of magnesium sulfate treatment to prevent CP are cited. Also explained are reasons why caution should be exercised in introducing such treatment.