Should I run regular network traffic on the iSCSI interface?
It is not recommended, as network resource contention will reduce iSCSI performance. Ideally, all iSCSI traffic should be separated from other network traffic by subnetting and by using VLANs or isolated physical LANs. A typical iSCSI connected server will have at least two network interfaces, one for regular LAN traffic on the LAN subnet, and second for iSCSI traffic on a private SAN subnet. Note that many target vendors employ various types of in-band managment, which results in occaisional non-iSCSI traffic on the iSCSI subnet.