Should everyone have their ApoE genotype tested?
No, the test is not intended to be used to screen the general population. It is intended to be used in very specific situations to give a doctor additional information. The majority of people have ApoE e3 and so will tend to have normal lipid metabolism. Most of the people with other ApoE combinations will never develop significant problems associated with their lipid metabolism, have type III hyperlipoproteinemia, or develop ApoE associated late onset AD.
