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Should domperidone be used for the treatment of gastro-oesophageal reflux in children?

April 26, 2017children domperidone gastro-oesophageal Reflux treatment Used

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Should domperidone be used for the treatment of gastro-oesophageal reflux in children?

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Pritchard DS; Baber N; Stephenson T Medicines and Healthcare Products Regulatory Agency, London, UK. deborah.pritchard@mhra.gsi.gov.uk AIM: To determine whether there is robust evidence of efficacy for domperidone in reducing the symptoms of gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) in children. METHODS: Systematic review of randomized controlled trials (RCTs). A search was made of the Cochrane Library Issue 2004 (Central Register of Controlled Trials and Database of Systematic Reviews), Medline (Pub-med) 1966 to present and Embase from 1974 to 2004, and reference citations of the RCTs that had been found electronically. RESULTS: Four RCTs were identified. Only the two older trials showed any benefits of domperidone on clinical symptoms of GORD in older children, which were the primary outcome measures.