Regarding the steroid sparers, I am under the impression that they are different than ACTH and that help in the weaning process. How do the sparers help and what are they?
It is also important to begin a “steroid saver” about one month after starting ACTH to maintain the neurological remission obtained by the ACTH. Despite a slow 20-week taper of ACTH or steroids, some patients will relapse unless they are also taking a steroid sparer. Azathioprine can be used at 3-5 mg/kg/day. Other steroid sparers are available, too. The use of these agents does not cause tumor regrowth.
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