Rather than saying the intravenous dose is given simultaneously with the oral dose, it is often stated that the intravenous dose is given concomitantly -what does this mean?
Depending upon the absorption characteristics of the oral dose, rather than give the intravenous dose at exactly the same time as the oral dose, the intravenous dose might be delayed until the tmax or given as an infusion over the same period as the drug is being absorbed. This is sometimes undertaken so that the clearance of the intravenous and oral drug are equivalent during the absorption phase but if the drug is absorbed relatively quickly, then this is probably unnecessary and the intravenous dose can be given along with the oral dose.
Related Questions
- If the intravenous dose is kept very low but the oral dose is administered at a therapeutically relevant level, how do you know that the plasma pharmacokinetics will be linear between the doses?
- Rather than saying the intravenous dose is given simultaneously with the oral dose, it is often stated that the intravenous dose is given concomitantly -what does this mean?
- What dose lackluster mean?
