Please give your opinion regarding amyloid theory of Alzheimer’s disease. What do you think of the current treatment strategies for Alzheimer’s and Huntington’s diseases?
Amyloid is an undeniable part of the AD story in that amyloid is either overproduced or not effectively cleared in all cases of AD. Of course, this does not mean that it is the only important pathway by which to intervene with therapies, but it is likely that effective anti-amyloid therapies will be helpful in the delay of onset and treatment of AD. There are numerous other strategies for the treatment of AD—some of which overlap with the strategies for treating other neurodegenerative diseases, such as Huntington’s disease (Doody RS. Alzheimer’s Dementia. 2008.). Strategies based upon risk factors have not proven to be effective (eg, vitamins to lower homocysteine, statins, estrogen, NSAIDs, DHA). Neurotransmitter-based therapies may still yield helpful agents—especially those targeting the serotonergic system, which is also impaired in AD. Anti-tau drugs may be developed to slow or block the development of neurofibrillary tangles, and several drugs that affect cellular or mitochondri
