Other than sucrose, what is the purpose of the other excipients in the final formulation of Helixate® FS?
A. Helixate® FS is lyophilized, which means it is rapidly freeze-dried under high vacuum. When a solution is freeze-dried, crystals form. The sodium, chloride, and calcium chloride protect the product during the freeze-drying process, while the glycine and histidine stabilize the crystal matrix. Important Safety Information Helixate® FS is a recombinant factor VIII (FVIII) product used to treat hemophilia A when there is a demonstrated deficiency of FVIII, a plasma clotting factor. Helixate® FS should be administered cautiously in patients with previous hypersensitivity to constituents of FVIII or known sensitivity to mouse or hamster protein. Helixate® FS should not be used by people with von Willebrand disease because it does not contain von Willebrand factor—a different protein associated with a different bleeding disorder. For more information about von Willebrand disease, please visit www.allaboutbleeding-us.com. Adverse events are generally minor. The most common events include i
