Optimising antiemetic therapy: what are the problems and how can they be overcome?
Author(s): Aapro M Affiliation(s): Clinique de Genolier, 1272, Genolier, Switzerland. maapro@genolier.net Publication date & source: 2005-06, Curr Med Res Opin., 21(6):885-97. Publication type: Review BACKGROUND: Management of chemotherapy- or radiotherapy-induced emesis has improved significantly following the introduction of the 5-HT3-receptor antagonists. Prophylactic use of these agents is recommended for the prevention of both chemotherapy- and radiotherapy-induced nausea and vomiting, given with a corticosteroid. Despite these advances, nausea and vomiting remain among the most feared and debilitating adverse effects of cytotoxic therapy. The shift towards a more elderly population of patients with cancer presents additional considerations for supportive care, with an emphasis on achieving control of nausea and vomiting, whilst minimising toxicity and avoiding drug-drug interactions. This review presents some of the key issues for consideration in optimising antiemetic therapy. T
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