Normal glucose tolerance and gestational diabetes mellitus: what is in between?
Di Cianni G; Seghieri G; Lencioni C; Cuccuru I; Anichini R; De Bellis A; Ghio A; Tesi F; Volpe L; Del Prato S Department of Endocrinology and Metabolism, Section of Diabetes and Metabolic Diseases, University of Pisa, 56126 Pisa, Italy. dicianni@immr.med.unipi.it OBJECTIVE: The aim of this article was to define the metabolic phenotype of pregnant women with one abnormal value (OAV) during an oral glucose tolerance test (OGTT) and to test whether OAV could be considered metabolically comparable to gestational diabetes mellitus (GDM) or a specific entity between GDM and normal pregnancy. RESEARCH DESIGN AND METHODS: After 100-g 3-h OGTTs, 4,053 pregnant women were classified as having GDM, OAV, or normal glucose tolerance (NGT). Those with OAV were subdivided into three subgroups: fasting hyperglycemia (one abnormal value at fasting during an OGTT), 1-h hyperglycemia (one abnormal value at 1 h during an OGTT [1h-OAV]), or 2- or 3-h hyperglycemia (one abnormal value at 2 or 3 h during an
