My sister (Who has not been diagnosed with AKU yet), would like to know at what age does the signs of AKU start in women, i.e. Back trouble, stones etc..?
In general patients, both male and female mention back pain starting in their twenties and thirties. The signs of alkaptonuria in women may present later than in males depending on the amount of weight bearing and joint stress an individual has had. Many of the other signs seen in alkaptonuria such as stones, eye and ear pigment changes, heart valve involvement occur at similar ages in men and women. However, even in the same family, siblings often have different levels of severity and age at presentation.
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