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My patient said he missed his dose of oxycodone last night, should the test result be negative?

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My patient said he missed his dose of oxycodone last night, should the test result be negative?

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It will depend largely on three factors: Dose, frequency of dose, and excretion capabilities. If the patient is prescribed oxycodone TID or QID then the urine should still test positive for the drug. If the patient is only prescribed single daily doses and they are capable of rapid metabolism/excretion, then the result may be negative due to screening cutoffs. The patient may also test positive for oxymorphone only as the retention time in the urine for this metabolite is longer than the parent drug.

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