My drug is undergoing enterohepatic circulation. Can I simulate the effects of meals on the plasma concentration-time profile?
Yes! GastroPlus includes a model for biliary secretion and enterohepatic circulation. You also have the ability to administer meals at specific times (through our Mixed Multiple Dosing feature), resulting in the emptying of gallbladder and reabsorption of the fraction of drug that was cleared through biliary secretion.
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