My analysis returned saying not enough homologs were found; what does this mean?
Prediction of functional residues using evolutionary conservation depends on finding enough homologous sequences to build a multiple sequence alignment and a phylogenetic tree. If fewer than 4 sequences are in a protein family, the analysis cannot be run. We use the query sequence to search the UniProt database for homologs using 4 iterations of PSI-BLAST; if this search fails to retrieve at least 3 unique homologs of the query, the analysis cannot proceed.
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