Most cell-culture media contain proteins derived from humans and/or animals. Is this also the case for the medium used for the cells that produce BeneFIX?
No. The CHO cells that produce BeneFIX were adapted to grow in a state-of-the-art, completely defined, serum-free medium lacking any components derived from blood or plasma products (eg, human serum albumin, transferrin, bovine serum albumin, bovine insulin).1 Moreover, purification of the BeneFIX produced by these cells does not involve the use of a monoclonal antibody step or the introduction of materials derived from blood or plasma products.
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