Mortality associated with selegiline in Parkinsons disease. What do the available data mean?
Author(s): Mizuno Y, Kondo T Affiliation(s): Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. Publication date & source: 1997-05, Drug Saf., 16(5):289-94. Publication type: Clinical Trial; Randomized Controlled Trial A recent study by the Parkinson’s Disease Research Group of the United Kingdom revealed higher mortality in patients with Parkinson’s disease who were treated with selegiline (deprenyl) compared with those who were not. In this article, the methodological limitations of the UK study are discussed. Although several problems exist with this study, the mortality rate was correct, since the data were obtained from a verifiable source. The question then is whether or not the higher mortality rate can be ascribed to selegiline. It is difficult to find answers to this question in the study data, and we will have to wait for the study authors’ final report. No other studies have reported higher mortality with selegiline. However, when prescribing sele
