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Methotrexate dose: should it be capped in patients with surface area >2 m2?

April 26, 2017area capped dose m2 methotrexate Patients

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Methotrexate dose: should it be capped in patients with surface area >2 m2?

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The EURAMOS-1 protocol states that doses should not be capped (please refer to section 9.1.8, pg 31 of v1.3 protocol). Drug dosage should be modified as little as possible and if necessary, treatment should be delayed in order to administer full doses.