May other drugs influence the withdrawal effects of alprazolam?
Alcohol, benzodiazepines, nonbenzodiazepines, corticosteroids and barbiturates that influence the GABAA system show cross-tolerance and similar withdrawal patterns. Cross-tolerance typically means that one drug will alleviate the withdrawal effects of another. Because of cross-tolerance within this class of sedatives and hypnotics, an alcoholic or barbiturate addict can be withdrawn using a benzodiazepine. For the same reason, phenobarbital can be used to manage benzodiazepine withdrawal. Compared to other benzodiazepines, however, alprazolam withdrawal may be inadequately covered by substitution. There have been reports of failure of other benzodiazepines to fully suppress the withdrawal symptoms of alprazolam. These failures have been attributed to incomplete cross-tolerance but may also reflect the use of an inadequate dosing regimen of the substituted benzodiazepine or the effects of concomitant drugs. Alprazolam detoxification should include an estimation of daily use and a slow w
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- May other drugs influence the withdrawal effects of alprazolam?
