May investigators use non-pharmaceutical grade compounds in animals?
• scientific necessity; • no availability of an acceptable veterinary or human pharmaceutical-grade compound; and • specific review and approval by the IACUC. Investigators and IACUCs should consider relevant animal welfare and scientific issues including safety, efficacy, and the inadvertent introduction of new variables. Cost savings alone do not adequately justify the use of non-pharmaceutical-grade compounds in animals. Although the potential animal welfare consequences of complications are less evident in non-survival studies, the scientific issues remain the same and the principles and need for professional judgment outlined above still apply.
• scientific necessity; • no availability of an acceptable veterinary or human pharmaceutical-grade compound; and • specific review and approval by the IACUC. Investigators and IACUCs should consider relevant animal welfare and scientific issues including safety, efficacy, and the inadvertent introduction of new variables. Cost savings alone do not adequately justify the use of non-pharmaceutical-grade compounds in animals. Although the potential animal welfare consequences of complications are less evident in non-survival studies, the scientific issues remain the same and the principles and need for professional judgment outlined above still apply. [A11] • May investigators use expired pharmaceuticals, biologics, and supplies in animals? The use of expired pharmaceuticals, biologics, and supplies is not consistent with acceptable veterinary practice or adequate veterinary care. Euthanasia, anesthesia and analgesia agents should not be used beyond their expiration date, even if a proce
