May antihistone antibodies replace antinuclear antibodies (ANA) as a predictor of uveitis in Juvenile idiopathic arthritis?
Antihistone antibodies (AHA) are an ANA subtype reported to be associated with uveitis in Juvenile idiopathic arthritis (JIA). Enzyme-linked immunoassays (E-ANA) are increasingly used as a more standardized alternative to the immunofluorescense method on Hep-2 cells (IF-ANA). E-ANA, however, show no association with uveitis and should not be used in the diagnostic work-up of JIA.
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